IARC Carcinogen Update

Dioxin Revisited: Developments Since the 1997 IARC Classification of Dioxin as a Human Carcinogen

In 1997 the International Agency for Research on Cancer (IARC) classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; the most potent dioxin congener) as a group 1 carcinogen based on limited evidence in humans, sufficient evidence in experimental animals, and extensive mechanistic information indicating that TCDD acts through a mechanism involving the aryl hydrocarbon receptor (AhR), which is p...

Chloroform Citation for Most Recent Iarc Review Iarc

Exposures to chloroform via showering, bathing, and swimming have been characterized much better since 1999, and these studies show that blood levels are usually higher via these routes than via drinking chlorinated water (Xu & Weisel, 2005; Caro & Gallego, 2007; Zwiener et al., 2007). Chloroform exposure has also been documented in various occupations (Ruder, 2006) and in microenvironments, su...

From testing to estimation: the problem of false positives in the context of carcinogen evaluation in the IARC monographs.

BACKGROUND Cancer epidemiology has been criticized for producing false-positive associations. The present analysis investigates the frequency of and factors contributing to false-positive findings in cancer epidemiology. METHODS The International Agency for Research on Cancer (IARC) Monographs Group 3 agents were examined to identify potential false-positive findings. Frequency estimates for ...

IARC on tamoxifen.

The Multi-Q web server provides an automated data analysis tool for multiplexed protein quantitation based on the iTRAQ labeling method. The web server is designed as a platform that can accommodate various input data formats from search engines and mass spectrometer manufacturers. Compared to the previous stand-alone version, the new web server version provides many enhanced features and flexi...

New Directions for IARC